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Treatment and Management of Cancer with Cordyceps militaris mushroom

Updated: Apr 26

Cordyceps militaris, also known as the Keeda jadi mushroom, is a remarkable medicinal fungus that has been attracting interest for its potential in cancer treatment and care. This vibrant orange mushroom, traditionally utilized in Chinese and Tibetan medicine, is rich in bioactive compounds such as cordycepin, polysaccharides, phenols, proteins, sterols, vitamins, micronutrients, antioxidants, and more, which provide significant benefits for cancer patients. A comprehensive overview of these molecules can be found here: The Pharmaceutical Potential of Cordyceps: Unlocking Nature's Treasure. Cordycepin, along with the polysaccharides, peptides, phenolic compounds, and other molecules in Cordyceps, appears to offer rejuvenating healing effects for cancer patients by neutralizing cancer cells and restoring metabolic balance.

नोट: कीड़ाजड़ी मशरुम कैंसर की चिकित्सा का विकल्प नहीं है. यह चिकित्सक की सलाह से ली जानी चाहिए।

Note: Cordyceps militaris or keeda Jadi mushroom is not a substitute for the ongoing cancer treatment. Consultation with doctor is necessary.

उपचार का दैनिक खर्च- 150 रुपए (2 ग्राम प्रतिदिन), Daily usage cost: Around Rs 150/- (2 grams per day for an adult).


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Cordyceps militaris as Adjuvent therapy for Cancer


There are numerous scientific research publications that highlight the efficacy of cordycepin, polysaccharides, extracts, and various fractions of Cordyceps militaris against cancer cells. It has advantages over other traditional supportive substances because it simultaneously exerts many healing effects along with killing cancer cells. Some of these mechanisms are summarized below:


  1. कैंसर कोशिकाओं में एपोप्टोसिस को प्रेरित करता है। Induces apoptosis in cancer cells.


  2. ट्यूमर खत्म करने के लिए नेचुरल किलर कोशिकाओं, टी-लसीकाणु, साइटोकाइन , इत्यादि का उत्पादन बढ़ाता है।

    Enhances natural killer (NK) cells, CD8+ T-lymphocytes, cytokine production, etc. to attack tumors and cancer cells,


  3. कैंसर कोशिकाओं को संवेदनशील करके कीमोथेरेपी और रेडियोथेरेपी की प्रभावकारिता को बढ़ाता है।

    Cordyceps militaris mushroom enhances the efficacy of chemotherapy and radiotherapy treatments by sensitizing cancer cells. These sensitized cancer cells are efficiently neutralized by our immune cells in the presence of the ongoing cancer treatment molecules, which alone may not be efficient in killing the cancer cells.


  4. कीमोथेरेपी और रेडियोथेरेपी के दुष्प्रभाव को कम करता है । With its excellent anti-inflammatory, anti-oxidant and detoxifying properties, Cordyceps militaris mushroom can efficiently minimize the side effects and toxicities of the ongoing chemotherapy and radiotherapy treatment. Thus, it improves the qualitative life during and after the treatment.


  5. शोथ को कम करता है । Chronic inflammation triggers the onset of most of the physiological distress and symptoms that mat further progress into one or another diseases. Cordyceps militaris mushroom has extraordinary anti-inflammatory potency that results faster relief and recovery during and after the cancer treatment regimes. Moreover, it also reduces the inflammatory responses generated by the ongoing treatments and its manifestations by the body.


  6. प्रतिरक्षा प्रणाली का द्विदिश न्यूनाधिकारक

    By acting as one of the most potent natural bidirectional immunomodulator, Cordyceps militaris is able to simultaneously activate the components of the immune system to kill the cancer cells as well as suppress the excessive inflammatory responses in order to yield optimum healing effects. This micro balancing the optimum immune responses is the key to maximize the positive outcomes of the ongoing cancer treatment simultaneously with minimizing the adverse effects.


  7. शरीर को ऊर्जावान बनाकर रोगी को बेहतर शारीरिक गतिविधियां करने में मदद करता है। Cordyceps militaris mushroom is a well known natural energy booster. It energizes the cancer warriors and help perform better physical activities.


  8. पाचन स्वास्थ्य में सुधार, पोषक तत्वों का अवशोषण और आंत माइक्रोबायोटा के पुनर्निर्माण में मदद करता है। Improves digestive health, absorption of nutrients and helps rebuild gut microbiota and vice-versa. It further may improve the conditions of cachexia and help faster recovery.


    A detailed account of mechanism of action is tabulated below-

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Exceptional Advantages of Cordyceps militaris over others supportive supplements


As outlined in the above sections, Cordyceps militaris mushroom may efficiently be used as an adjuvant therapy agent to enhance cancer immunity and kill the cancer cells. Besides these, it also exhibits numerous health benfits that complements faster recovery, healing and overall well being. Importantly, it can also be used to treat and manange one or more comorbodities that most of supplements lack the ability to.

Elixir of Life: Unveiling Health Benefits of Cordyceps militaris Mushroom
Elixir of Life: Unveiling Health Benefits of Cordyceps militaris Mushroom

Availability and Cost of Cordyceps militaris mushroom

Cordyceps militaris mushroom is available in a wide price range depending on its nutrient profile, type and quality of raw materials, extent of aseptic conditions being adopted throughout the cultivation, harvesting, drying, and storage process, etc.

In most circumstances, the daily cost is around Rs 100-200 for 2 grams per day of usage for an average adult. Besides of lower cost compared to other cancer treatment regimes, this msuhroom is also widely available in the market. However, finding a good and reliable source may be an isuue.


Cordcyeps enhances the efficacy of Chemotherapy, Radiotherapy, etc. treatments- a few citations


  1. Jo, E., Jang, H., Yang, K. E., Jang, M. S., Huh, Y. H., Yoo, H., Park, J., Jang, I., & Park, S. J. (2020). Cordyceps militaris Exerts Antitumor Effect on Carboplatin-Resistant Ovarian Cancer via Activation of ATF3/TP53 Signaling In Vitro and In Vivo. Natural Product Communications, 15(1). https://doi.org/10.1177/1934578x20902558

  2. Liao, X., Gao, Y., Zhao, H., Zhou, M., Chen, D., Tao, L., Guo, W., Sun, L., Gu, C., Chen, H., Xiao, Z., Zhang, J., He, M., & Lin, L. (2021). Cordycepin reverses cisplatin resistance in non-small cell lung cancer by activating AMPK and inhibiting AKT signaling pathway. Frontiers in Cell and Developmental Biology, 8. https://doi.org/10.3389/fcell.2020.609285

  3. Oh, S., Lee, K. W., Madhi, H., Jeong, J., Park, S., Kim, M., Lee, Y., Han, H., Hwangbo, C., Yoo, J., & Kim, K. D. (2020). Cordycepin resensitizes T24R2 Cisplatin-Resistant human bladder cancer cells to cisplatin by inactivating ETS-1 dependent MDR1 transcription. International Journal of Molecular Sciences, 21(5), 1710. https://doi.org/10.3390/ijms21051710

  4. Gao, Y., Chen, D., Zhou, M., Zheng, Z., He, M., Huang, S., Liao, X., & Zhang, J. (2020). Cordycepin enhances the chemosensitivity of esophageal cancer cells to cisplatin by inducing the activation of AMPK and suppressing the AKT signaling pathway. Cell Death and Disease, 11(10). https://doi.org/10.1038/s41419-020-03079-4

  5. Huang, H., Li, X., Wu, W., Liu, C., Shao, Y., Wu, X., & Fu, J. (2024). Cordycepin enhances the therapeutic efficacy of doxorubicin in treating Triple-Negative breast cancer. International Journal of Molecular Sciences, 25(13), 7077. https://doi.org/10.3390/ijms25137077

  6. Li, X., Liu, Q., Xie, S., Wu, X., & Fu, J. (2023). Mechanism of action of cordycepin in the treatment of hepatocellular carcinoma via regulation of the Hippo signaling pathway. Deleted Journal, 13(2), 1040–1054. https://doi.org/10.26599/fshw.2022.9250090

  7. Jo, E., Jang, H., Shen, L., Yang, K. E., Jang, M. S., Huh, Y. H., Yoo, H., Park, J., Jang, I. S., & Park, S. J. (2020). Cordyceps militaris Exerts Anticancer Effect on Non–Small Cell Lung Cancer by Inhibiting Hedgehog Signaling via Suppression of TCTN3. Integrative Cancer Therapies, 19. https://doi.org/10.1177/1534735420923756


Cordyceps Boosts the Immune system's response to Cancer- a few citations

  1. Chaicharoenaudomrung, N., Kunhorm, P., & Noisa, P. (2023). Cordycepin Enhances the Cytotoxicity of Human Natural Killer Cells against Cancerous Cells. Biological and Pharmaceutical Bulletin, 46(9), 1260–1268. https://doi.org/10.1248/bpb.b23-00221

  2. Zheng, Q., Sun, J., Li, W., Li, S., & Zhang, K. (2020). Cordycepin induces apoptosis in human tongue cancer cells in vitro and has antitumor effects in vivo. Archives of Oral Biology, 118, 104846. https://doi.org/10.1016/j.archoralbio.2020.104846

  3. Gao, Y., Chen, D., Zhou, M., Zheng, Z., He, M., Huang, S., Liao, X., & Zhang, J. (2020b). Cordycepin enhances the chemosensitivity of esophageal cancer cells to cisplatin by inducing the activation of AMPK and suppressing the AKT signaling pathway. Cell Death and Disease, 11(10). https://doi.org/10.1038/s41419-020-03079-4

  4. Hsu, P., Lin, Y., Yeh, E., Lo, H., Hsu, T., & Su, C. (2017). Cordycepin and a preparation from Cordyceps militaris inhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signaling in a murine oral cancer model. Oncotarget, 8(55), 93712–93728. https://doi.org/10.18632/oncotarget.21477

  5. Zhou, Q., Zhang, Z., Song, L., Huang, C., Cheng, Q., Bi, S., Hu, X., & Yu, R. (2018). Cordyceps militaris fraction inhibits the invasion and metastasis of lung cancer cells through the protein kinase B/glycogen synthase kinase 3β/β‑catenin signaling pathway. Oncology Letters. https://doi.org/10.3892/ol.2018.9518

  6. Quan, X., Kwak, B. S., Lee, J., Park, J. H., Lee, A., Kim, T. H., & Park, S. (2020). Cordyceps militaris Induces Immunogenic Cell Death and Enhances Antitumor Immunogenic Response in Breast Cancer. Evidence-based Complementary and Alternative Medicine, 2020(1). https://doi.org/10.1155/2020/9053274

  7. Zhang, Y., Zhang, X. X., Yuan, R. Y., Ren, T., Shao, Z., Wang, H. F., Cai, W. L., Chen, L. T., Wang, X. A., & Wang, P. (2018). Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo. OncoTargets and Therapy, Volume 11, 4479–4490. https://doi.org/10.2147/ott.s164670

  8. Hwang, I., Oh, S. Y., Jang, H., Jo, E., Joo, J. C., Lee, K., Yoo, H., Lee, M. Y., Park, S. J., & Jang, I. (2017). Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression. PLoS ONE, 12(10), e0186489. https://doi.org/10.1371/journal.pone.0186489



 
 
 

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